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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T5036 | Cangrelor tetrasodium | GPR , P2Y Receptor | |
Cangrelor tetrasodium is a reversible and selective antagonist of platelet P2Y12, with prompt and potent antiplatelet effects. | |||
T5460 | Mofezolac | COX | |
Mofezolac (formerly known as Disopain or N-22) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index > 6000 | |||
T6594 | MNS | Syk , Src , p97 | |
MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively. | |||
T2629 | UNC2881 | TAM Receptor | |
UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively. | |||
T15031 | CYM50260 | Others , LPL Receptor | |
CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R. | |||
T6236 | Ozagrel | OKY-046,Domenan | Thrombin , Prostaglandin Receptor |
Ozagrel (Domenan) is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral isch... | |||
T15047 | Dacisteine | N,S-Diacetyl-L-cysteine | Others |
Dacisteine (N,S-Diacetyl-L-cysteine) is an inhibitor of New Delhi metallo-beta-lactamase-1 (NDM-1, IC50 = 1000 μM). | |||
T4190 | Ticlopidine | PCR 5332,Ticlid | ATPase , Adiponectin receptor |
Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor. | |||
T8719 | SC99 | Apoptosis , JAK , STAT | |
SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activiti... | |||
T1893 | Parmodulin 2 | ML 161 | Protease-activated Receptor |
Parmodulin 2 (ML 161) is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). It also inhibits thromb... | |||
T6625 | Ozagrel hydrochloride | Ozagrel HCl,OKY-046 HCl | Thrombin , Prostaglandin Receptor |
Ozagrel hydrochloride (OKY-046 HCl) is a selective thromboxane A(2) synthetase inhibitor used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia. | |||
T0230 | Prasugrel | LY640315,CS-747,PCR 4099 | P2Y Receptor |
Prasugrel (CS-747) is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNSTABLE ANGINA and MYOCARDIAL INFARCTION, as well as in those... | |||
T16164 | MY-5445 | N-(3-chlorophenyl)-4-phenylphthalazin-1-amine | PDE |
MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM). | |||
T2569 | Chlorotrianisene | tris(p-methoxyphenyl)chloroethylene,CTA,tri-p-anisylchloroethylene,TACE | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , COX |
Chlorotrianisene (tri-p-anisylchloroethylene) is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), with predominantly estrogenic but... | |||
T0182L | Clopidogrel hydrogen sulfate | (S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel | P450 , P2Y Receptor |
Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) , a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets and platelet adhesion and aggregation. | |||
T6952 | Prasugrel Hydrochloride | LY 640315,PCR 4099 (hydrochloride),Effient Hydrochloride,LY 640315 Hydrochloride,Prasugrel HCl | P2Y Receptor |
Prasugrel Hydrochloride (LY 640315 Hydrochloride) is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome. | |||
T15757 | Limaprost | 17α,20-dimethyl-δ2-PGE1,OP1206,ONO1206 | PGE Synthase |
Limaprost (17α,20-dimethyl-δ2-PGE1) is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency.It is a potent and orally active vasodilator. Limaprost increases blood... | |||
T1618 | Dipyridamole | Persantin,Dypyridamole,Dipyridamol,NSC-515776,Dipyudamine | PDE |
Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation. | |||
T13210 | Trombodipine | PCA-4230 | Antibiotic |
Trombodipine (PCA-4230) is a platelet aggregation inhibitor with antithrombotic activity and protection against Listeria monocytogenes. | |||
T8575 | ENFENAMIC ACID | Platelet aggregation | |
Enfenamic acid is a platelet aggregation inhibitor and with antirheumatic. | |||
T3608 | Carbasalate calcium | Rheomin,Omegin,Alcacyl,Iromin,Solupsan,Carbasalate Calcium | Platelet aggregation |
Carbasalate calcium (Rheomin) is an analgesic, antipyretic, and anti-inflammatory drug, as well as a platelet aggregation inhibitor. | |||
T31213 | Dazmegrel | UK-38,485,UK 38485,UK 38,485,UK38,485,UK-38485 | PPAR |
Dazmegrel (UK 38,485) is a potent and specific thromboxane A2 (TXA2) synthase inhibitor for the prevention of increased whole platelet aggregation in normal pregnancy. | |||
T9887 | Ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate | Platelet aggregation | |
ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate is a platelet aggregation inhibitor. | |||
T25635 | Lateritin | Bassiatin | Acyltransferase |
Lateritin (Bassiatin) is An Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor and a platelet aggregation inhibitor from the mycelial cake of Gibberella lateritium. Bassiatin is the (3S,6R) isomer. | |||
T0362 | Ticlopidine hydrochloride | Ticlodone,Ticlopidine HCl,Ticlodix | Adenosine Receptor |
Ticlopidine hydrochloride (Ticlodix) is an effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES. | |||
T15577 | Indobufen | Ibustrin | COX |
Indobufen (Ibustrin) is an inhibitor of platelet aggregation and is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue fac... | |||
T12808 | S-Nitroso-N-acetyl-DL-penicillamine | SNAP | NO Synthase |
S-Nitroso-N-acetyl-DL-penicillamine (SNAP) acts as a stable inhibitor of platelet aggregation, is a nitric oxide donor and . | |||
T24567 | Octimibate | Octimibato | Prostaglandin Receptor |
Octimibate (Octimibato) is a non-prostaglandin platelet aggregation inhibitor and cyclic prostaglandin agonist.Octimibate is used in the treatment of cardiovascular disease and can be used to study atherosclerosis and th... | |||
T10502 | Benzcyclane | Benzcyclan,Bencyclane | Others , Platelet aggregation |
Benzcyclane (Benzcyclan) is an inhibitor of platelet aggregation and also a vasodilator that can be used in a variety of peripheral circulation disorders. | |||
T29097 | VAS 3947 | VA-S3947,VA S3947,VAS3947 | Apoptosis , NADPH-oxidase |
VAS 3947 is a specific inhibitor of NADPH oxidase (NOX).VAS 3947 has a potent anti-platelet effect, inducing apoptosis through UPR activation, mainly due to protein aggregation and misfolding, independent of anti-NOX act... | |||
T15130 | Dilazep dihydrochloride | Others | |
Dilazep dihydrochloride is an adenosine uptake inhibitor. It also inhibits ischemic damage, membrane transport of nucleosides, and platelet aggregation. It has cerebral and coronary vasodilating action through the enhanc... | |||
T6040 | Aloxistatin | E64d,Loxistatin,E64c ethyl ester | SARS-CoV , Cysteine Protease |
Aloxistatin (E64d) is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with... | |||
T0179 | Ticagrelor | AR-C 126532XX,AZD6140 | P450 , P2Y Receptor |
Ticagrelor (AR-C 126532XX), produced by AstraZeneca, is an inhibitor of platelet aggregation. Unlike clopidogrel, ticagrelor is not a prodrug required metabolic activation. The drug was approved for use in the European U... | |||
T76844 | Abciximab | C7E3 | Integrin |
Abciximab (C7E3) is a mouse/human chimeric monoclonal antibody that is a potent glycoprotein IIb/IIIa inhibitor. Abciximab has anti-platelet aggregation and leukocyte adhesion, acting by binding to glycoproteins IIb/IIIa... | |||
T17039 | Terbogrel | BIBV 308SE | Prostaglandin Receptor |
T23899 | Cloricromen | O=C(OCC)COC1=CC=C(C(O2)=C1Cl)C(C)=C(CCN(CC)CC)C2=O | |
Cloricromen is an inhibitor of platelet aggregation. | |||
T68832 | Itazigrel | ||
Itazigrel is a platelet aggregation inhibitor. | |||
T25364 | Efegatran | LY 294468,LY294468,LY-294468 | |
Efegatran is a hematologic agent and platelet aggregation inhibitor. | |||
T68996 | AQ 1989 | ||
AQ 1989 is a platelet aggregation inhibitor. | |||
T24745 | RUC-1 | RUC1 | |
RUC-1 is an αIIbβ3-selective ADP-induced platelet aggregation inhibitor. | |||
T69154 | AY-16804 | ||
AY-16804 is an inhibitor of platelet aggregation. | |||
T68995 | AQ 1994 | ||
AQ 1994 is a platelet aggregation inhibitor. | |||
T11629 | Ifenprodil glucuronide | Others | |
Ifenprodil glucuronide, a derivative of Ifenprodil, is a vasodilator and an inhibitor of platelet aggregation. In contrast to Ifenprodil, Ifenprodil glucuronide does not affect platelet aggregation nor arterial contracti... | |||
T71367 | OM-4842 | ||
OM-4842 is a platelet aggregation inhibitor from Streptomyces. | |||
T68222 | DN 9693 | ||
DN 9693 is a potent inhibitor of platelet aggregation. | |||
T68902 | Talosalate | ||
Talosalate is an inhibitor of blood platelet aggregation. | |||
T71146 | Salvinone | ||
Salvinone is a platelet aggregation inhibitor isolated from Salvia miltiorrhiza. | |||
T68251 | Domipizone | ||
Domipizone is a platelet aggregation inhibitor, cardiotonic and vasodilator. | |||
T15238 | Epoprostenol sodium | Prostaglandin I2 sodium salt,Prostacyclin sodium salt,Flolan | Others |
Epoprostenol sodium is a potent inhibitor of platelet aggregation used in pulmonary hypertension and transplantation. | |||
T26072 | Rhazimine | ||
Rhazimine is an indole alkaloid. It is a dual inhibitor of arachidonic acid metabolism and platelet activating factor-induced platelet aggregation. |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T6S0139 | Neobavaisoflavone | Apoptosis , DNA/RNA Synthesis | |
1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can si... | |||
T3781 | Jujuboside B | Others | |
Jujuboside B has potent inhibitory effects on collagen-, thrombin-, AA-, and ADP-induced aggregation, and also exhibits superior protection on the thromboembolic model. | |||
T3S1591 | Notoginsenoside Fc | Others , Autophagy | |
1. Notoginsenoside Fc has perfect anti-platelet aggregatory effect. | |||
T0853 | Adenosine | D-Adenosine,Adenine riboside | Apoptosis , Nucleoside Antimetabolite/Analog , Endogenous Metabolite , Autophagy |
Adenosine (D-Adenosine) is a ribonucleoside comprised of adenine bound to ribose, with vasodilatory, antiarrhythmic and analgesic activities. | |||
TN2244 | Sulfuretin | NF-κB , Autophagy | |
Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 thr... | |||
T1626 | Prostaglandin E1 | PGE1,Alprostadil | Endogenous Metabolite , Prostaglandin Receptor |
Prostaglandin E1 (Alprostadil) is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Prostaglandin E1 is a potent vasodilator agent that increases peripheral blood flow, in... | |||
TN4222 | Homoeriodictyol 7-O-β-D-glucoside | Homoeriodictyol 7-O-glucoside | Others , Platelet aggregation |
Homoeriodictyol 7-O-β-D-glucoside (Homoeriodictyol 7-O-glucoside) is a natural product from Viscum coloratum(Kom.)Nakai. Homoeriodictyol 7-O-β-D-glucoside is an antagonist of platelet-activating factor (PAF). | |||
TN6924 | Anhydrosafflor yellow B | (2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1,AHSYB | Others |
Anhydrosafflor yellow B ((2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,... | |||
T12164 | N6-(4-Hydroxybenzyl)adenosine | Para-topolin riboside | P2Y Receptor |
N6-(4-Hydroxybenzyl)adenosine (Para-topolin riboside) is a platelet aggregation inhibitor. | |||
T28551 | Ro 09-0680 | Ro-09-0680,Ro 09 0680 | |
Ro 09-0680, a compound derived from Salvia miltiorrhiza, is a potent inhibitor of collagen-induced platelet aggregation in rabbits with potential anti-inflammatory activity for the study of cardiovascular disease. | |||
T3734 | 3',4'-Dihydroxyacetophenone | Qingxintong,4-Acetylpyrocatechol | Tyrosinase , Platelet aggregation |
3',4'-Dihydroxyacetophenone (Qingxintong) is an active constituent of Chinese medicine. It is platelet aggregation Inhibitor and also has anti-arrhythmia activity. | |||
T3S0645 | N-trans-Feruloyltyramine | Feruloyltyramine,N-Feruloyltyramine,Moupinamide | Others , COX |
1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-s... | |||
TN1254 | 3'-Methoxydaidzein | Sodium Channel | |
3'-Methoxydaidzein is a dual isoflavone and Sodium Channel inhibitor. 3'-Methoxydaidzein inhibited NaV1.7, NaV1.8 and NaV1.3 with IC50 of 181 nM, 397 nM and 505 nM, respectively. 3'-Methoxydaidzein was specific for colla... | |||
T17273 | YM-254890 | Others | |
YM-254890 inhibits platelet aggregation induced by ADP by blocking the P2Y1 signal transduction pathway (IC50: below 0.6 μM). YM-254890 is a selective Gαq/11 protein inhibitor. YM-254890 displays no inhibition of other G... | |||
T82003 | Juniferdin | ||
Juniferdin, a Protein disulfide isomerase (PDI) inhibitor with an IC50 of 3.5 μM, is designed to prevent HIV transmission. It exhibits cytotoxic properties and inhibits platelet aggregation [1]. | |||
T64246 | Cinchonine monohydrochloride hydrate | ||
Cinchonine ((8R,9S)-Cinchonine) monohydrochloride hydrate is a natural and potent antimalarial agent and an inhibitor of human platelet aggregation. apoptosis in human hepatocellular carcinoma cells and inhibits adipogen... | |||
T36295 | Echistatin TFA | ||
Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorpti... | |||
T72916 | Justicidin B | ||
Justicidin B, a potent lignan, exhibits anticancer and proapoptotic properties, additionally serving as a bone resorption inhibitor. This compound demonstrates robust antiviral, fungicidal, and antiprotozoal effects, alo... | |||
TN5221 | (-)-Variabilin | ||
Variabilin, a novel inhibitor of human platelet aggregation, it is a potent RGD (Arg-Gly-Asp)-containing antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; αIIbβ3) and the vitronectin receptor αvβ3.... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPH-00213 | Disintegrin batroxostatin Protein, Bothrops atrox, Recombinant (His & Myc) | Bothrops atrox | E. coli |
Inhibits fibrinogen interaction with platelets. Acts by binding to the glycoprotein IIb-IIIa receptor (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor a... | |||
TMPY-00741 | CXCL4 Protein, Human, Recombinant | Human | E. coli |
Platelet factor 4 (PF4), also known as chemokine (C-X-C motif) ligand 4 (CXCL4), is a small cytokine belonging to the CXC chemokine family. CXCL4/PF4 is released from the alpha-granules of activated platelets and binds w... |